Myelodysplastic Syndromes
The myelodysplastic syndromes (MDS) are a diverse collection of haematological conditions united by ineffective production (or dysplasia) of myeloid blood cells and risk of transformation to acute myeloid leukaemia (AML).
MDS has been found in humans, cats and dogs. Anaemia requiring chronic blood transfusion is frequently present.
MDS are bone marrow stem cell disorders resulting in disorderly and ineffective blood production manifested by defects in blood-forming cells.
In a majority of cases, the course of disease is chronic with gradually worsening cytopenias due to progressive bone marrow failure.
Approximately one-third of patients with MDS progress to AML within months to a few years.
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